Theory Layer
A first-principles theoretical framework for understanding biological aging.
- First Principles Thinking
- TRCS Framework as the core model
- Theory-driven integration of aging biology
Research Focus
Our research is organized around a unified scientific framework, progressing from first-principles theory to biological mechanisms and disease applications.
Research Strategy
A three-layer research architecture connecting theory, biological mechanisms, and disease-relevant inquiry.
Mechanistic Biology
Molecular and systems-level mechanisms underlying aging processes.
- rDNA biology and genome stability
- Telomere dynamics
- p53-mediated regulatory programs
- Cellular senescence systems
Disease-Relevant Research
Mapping aging mechanisms to multiple degenerative disease systems through comparative biology.
- Cancer biology
- Cardiovascular and cerebrovascular diseases
- Other age-related degenerative diseases
Theory to Disease Application
Current Research Focus
Refinement of the TRCS Framework
Refining the theoretical foundations of the TRCS framework through conceptual analysis, mathematical modeling, and integration of emerging biological evidence.
rDNA Expansion Mechanisms
Investigating the molecular mechanisms responsible for ribosomal DNA maintenance, expansion, and genome stability across the lifespan.
Cancer and Immunosenescence
Cancer is one of the leading causes of death worldwide. We study the biological mechanisms linking aging, immune decline, and cancer progression.
Cardiovascular and Cerebrovascular Diseases
Cardiovascular and cerebrovascular diseases remain the leading cause of death worldwide. We study the biological mechanisms underlying vascular aging and degenerative disease.
Long-Term Outlook
Future Directions
Future research will extend the TRCS framework through collaboration with international research institutions, broadening its application to a wider range of age-related degenerative diseases beyond cancer and cardiovascular and cerebrovascular disorders.